How bad are phenibut withdrawals

Recently, a Quora.com user asked Better Brain, “How bad are phenibut withdrawals?” If you are interested in purchasing phenibut (and using it responsibly), you can buy it from Nootropics Depot. Beta-alanine is mentioned below to ease withdrawals (we also love it in our homemade pre-workout) and it can be found in capsules at Amazon.com or in powder form.

Phenibut Withdrawal Symptoms

Phenibut withdrawals are very rare, but can have some serious symptoms. Some of the possible symptoms include[1]:

  • agitation
  • anxiety
  • appetite reduction
  • cognitive deficits
  • depression
  • depersonalization
  • dizziness
  • fatigue
  • hallucinations
  • heart palpitations
  • insomnia
  • irritability
  • muscle tension
  • nausea
  • primal fear
  • rapid heartbeat
  • restlessness
  • sleep disturbances
  • tremors
  • vomiting

phenibut addiction. person holding bars. phenibut withdrawal

American Addiction Centers says “Quitting cold turkey seems to be rather intense for most people. Thus, abruptly stopping use is not a recommended course of action. It also does not give the brain a chance to heal or adjust to changes in neurotransmitter levels. People used to particularly high doses can experience very serious implications[2].”

Phenibut Addiction Study

There are few documented cases of withdrawals after long-term regular usage, but one study of a successful recovery:

At the time of the assessment, he was abstinent from alcohol and actively using the ‘supplements’ phenibut (for 10 months) and kratom (for 2 years). He was taking 8 g of phenibut and 18 g of kratom per day. The patient found these two ‘supplements’ very helpful for coping with withdrawal symptoms from alcohol, benzodiazepines and poppies. He was unable to stop using them. He made several attempts to decrease his use of phenibut, but experienced heightened anxiety, anger and irritability. He felt very hostile towards his work colleagues and family members. He was isolating himself at home to keep from losing his temper. Discontinuation of kratom precipitated mild-to-moderate opioid withdrawal symptoms.

Our treatment strategy was to substitute prescription medications with less abuse potential and better-known pharmacological profiles for the ‘supplements’ phenibut and kratom, and then taper off. Baclofen was selected for treatment of phenibut dependence due to the similarity of its structure and pharmacological profile to that of phenibut.

After 9 weeks of gradual substitution with baclofen, the patient was able to stop using phenibut completely. He was then tapered off baclofen over the following 12 weeks. He experienced intermittent anxiety, irritability and cravings for alcohol over the course of the treatment. At visit 9 (14 weeks in treatment), the patient was started on citalopram 20 mg once daily to manage re-emerging anxiety and depression….

This is the first and only case of phenibut dependence observed in our clinic out of approximately 1000 patients treated annually. We could locate only one published clinical case related to phenibut, which is a case of phenibut withdrawal, describing symptoms very similar to those experienced by our patient [3].

Phenibut Withdrawal Anecdotes

A Reddit user used beta-alanine to help ease withdrawal symptoms from regular usage of up to 20g/day phenibut:

Beta-alanine paraesthesia (tingling) on face and body, and fatigue. Little or no anxiety, but body temperature felt subjectively hot. Heart rate felt faster, but overall felt calm. Blood pressure was stabilized, heart rate was usual. Temperature range from 97.5-99.1 throughout the next 3 days of solely taking beta-alanine. Difficulty sleeping, but sleep occurred with only 4g of beta-alanine 1-2 hours before bed. Overall, the withdrawal symptoms were still there albeit extremely mild. Psychosis may have been occurring, but as the one study says–the patient was usually lucid in conversation! Others said I looked, and acted fine. Pupils were dilated. At the end of the 3 and 4th days, I felt mostly fine but I could no longer run the experiment because of fatigue.

…And not from just dependency, but I suffered almost no withdrawal. No anxiety! It was miraculous! Because I could spend my whole day in museums and the library just as I had planned. And the whole time I had a trunk full of baclofen and other medicine just in case the experiment derailed but it did not. I just began experiencing side effects of the beta alanine because I was feeling increasingly tingly and exhausted. No depression, or sadness, no anxiety. I felt myself. I ended the experiment around hour 80-90 because I was sleeping 4-6 hours at a time and waking up feeling much more exhausted. I think I ideally should’ve kept going until day 7-10 to see the phenibut fully leave my body and for the GABAb receptors to reset. And then see. But I simply had to get back to work. But yes. Now I’m taking 5g/d with much less worries because beta-alanine is there! I think this is big news for the community. I hope to get it out there again, and to see if it helps others[4].

Footnotes

[1] Phenibut Withdrawal Symptoms: List of Possibilities

[2] Phenibut Withdrawal, Tapering, and Detox

[3] https://www.ncbi.nlm.nih.gov/pmc…

[4] My effective method to beat withdrawal from high dose, chronic phenibut usage: • r/Nootropics

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